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Description
Keep in mind that the use of Lumigan eye drops does not represent a cure for glaucoma. It is a treatment prescribed by doctors in patients with glaucoma, which reduces the risk of optic nerve damage and in consequence blindness.
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A structure in our eyes constantly secrete a liquid which has the function of providing the nutrients which are needed. In order for the eye to function properly, a balance must be kept between the secretion and the excretion function.
When the excretion function is very slow, the liquid above mentioned will start to build up inside the eye, thus causing a spike in the intra ocular pressure.
If this balance is not corrected, the high intra ocular pressure will lead to damage to the optic nerve, and in time to blindness. Lumigan eye drops facilitate the excretion of the liquid, maintaining a stable balance between secretion and excretion.
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The accepted dose for Lumigan eyedrop solution is one drop of 0.01% solution in the eye affected by glaucoma. If both are are affected, than one drop should be administered in each eye. To apply the drops, first remove your contact lenses as they may absorb a part of the active ingredients which are contained by Lumigan eyedrops.
After applying the eye drops directly into the eye, gently close and open the eye in order to spread the solution all across the surface. Do not use your hands to rub your eyes, as this may result in doing more damage than good.Because the effects of this drug have not been studied on patients with liver or renal disease, consult your physician before administering the drops if you are known to have one or both types of the above mentioned diseases.
If you are allergic or have hipersensitivity to any of the active ingredients of the Lumigan Eyedrops, do not administer the drug. Consult the list of active ingredients before applying Lumigan Eyedrops. Possible side effects of using this drug may include redness of the eye, eyes changing colour, itching, swelling, dizziness.
If you are experiencing any of these symptoms on a daily basis, seek physician care immediately.
Explore the following products in this category: XALATAN and CAREPROST
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How does Bimatoprost work?
Composition, form of release and packaging
- Eye drops - 1 ml.:
- Active principle: bimatoprost 0.3 mg;
- Excipients: benzalkonium chloride - 0.05 mg, sodium chloride - 8.3 mg, citric acid monohydrate - 0.14 mg, sodium hydrogen phosphate heptahydrate - 2.68 mg, sodium hydroxide - up to pH 7.3, hydrochloric acid - up to pH 7.3, water for injections - up to 1 ml.
- Bottle with stopper-dropper, 2.5 ml.
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Pharmacotherapeutic group
Antiglaucoma agent. Bimatoprost is a synthetic prostamide structurally related to prostaglandin F2α that does not act through known prostaglandin receptors. Bimatoprost selectively mimics the effects of a recently discovered biosynthetic substance, the prostamides. However, the structure of prostamide receptors has not yet been identified.
pharmacokinetics
Bimatoprost penetrates well into the human cornea and sclera in vitro. After instillation by adults, the systemic exposure of bimatoprost is very low, no accumulation of the active substance was observed. After the introduction of one drop of the drug into both eyes 1 time / day for 2 weeks, the concentration in the blood reached a maximum 10 minutes after the dose, and within 1.5 hours this indicator was below the level of detection (0.025 ng/ml). The mean values of Cmax and AUC0-24 h were approximately the same on days 7 and 14: approximately 0.08 ng/mL and 0.09 ng × h/mL, respectively, indicating that the bimatoprost Css was reached. within 1 week of instillation. Bimatoprost is sparingly distributed to body tissues, and the Vd at steady state is 0.67 l/kg. In human blood, bimatoprost is found mainly in plasma. Plasma protein binding of bimatoprost is about 88%. Bimatoprost reaches the systemic circulation mainly unchanged. Then there is oxidation, N-desethylation and glucuronidation with the formation of a series of metabolites.
Bimatoprost is mainly excreted via the kidneys. Up to 67% of the dose administered intravenously to healthy adult volunteers was excreted in the urine, 25% in the faeces. T1/2 after intravenous administration was approximately 45 minutes, the total blood clearance was 1.5 l/h/kg.
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pharmacodynamics
Bimatoprost lowers intraocular pressure by increasing aqueous outflow through the trabecular meshwork and increasing uveoscleral outflow.
The decrease in intraocular pressure begins approximately 4 hours after the first injection, the maximum effect is reached after approximately 8-12 hours, and the effect lasts for at least 24 hours.
Based on clinical studies, there was no significant effect of bimatoprost on heart rate and blood pressure.
Indications for use
Open-angle glaucoma and ophthalmohypertension in adults (as monotherapy or in combination with beta-blockers).
Contraindications for use
Hypersensitivity to bimatoprost; age up to 18 years.
Caution is required when using bimatoprost preparations for the treatment of patients with known risk factors for macular edema (eg, in patients with aphakia, in patients with pseudophakia and ruptured posterior lens capsule); in patients with a history of serious eye infections (for example, those caused by the herpes simplex virus) or iritis/uveitis.
Pregnancy and lactation
Contraindicated in children and adolescents under 18 years of age.
There are no clinical study data on the use of bimatoprost during pregnancy. The use of bimatoprost during pregnancy is not recommended unless clearly indicated.
Based on preclinical animal studies, reproductive toxicity has been demonstrated with the use of bimaptoprost at high doses that are toxic to the maternal body.
It is not known whether bimatoprost is excreted in human breast milk. Animal studies have shown that bimatoprost is excreted in breast milk. The decision to continue/discontinue breast-feeding or to continue/discontinue treatment with bimatoprost should be made taking into account the benefits of breast-feeding for the infant and the benefits of therapy for the mother.
Side effects
Definition of frequency categories of adverse reactions: very often (<1/10); often (<1/100 to <1/10); infrequently (<1/1000 to <1/100); rarely (<1/10,000 to <1/1000); very rare (<1/10,000), frequency unknown (frequency cannot be estimated from the available data).
From the nervous system: often - headache; infrequently - dizziness.
On the part of the organ of vision: very often - conjunctival injection, itchy eyes, eyelash growth; often: superficial punctate keratitis, corneal erosion, burning eyes, eye irritation, allergic conjunctivitis, blepharitis, decreased visual acuity, asthenopia, conjunctival edema, foreign body sensation in the eye, dry eye, eye pain, photophobia, tearing, discharge from the eyes, blurred vision, increased pigmentation of the iris, darkening of the eyelashes; infrequently: retinal bleeding disorders, uveitis, cystoid macular edema, iritis, blepharospasm, eyelid retraction, periorbital erythema; unknown frequency - enophthalmos. In very rare cases, corneal calcification has been reported with the use of phosphate-containing eye drops in patients with concomitant significant corneal damage.
From the cardiovascular system: often - arterial hypertension.
On the part of the hepatobiliary system - often a deviation from the norm of biochemical indicators of liver function.
On the part of the skin and subcutaneous tissues: infrequently - hirsutism.
General reactions: infrequently - asthenia.
drug interaction
There was a decrease in the hypotensive effect of bimatoprost when used together with other prostaglandin analogues in the treatment of ophthalmohypertension or glaucoma.
Dosage and administration
1 drop of bimatoprost in the affected eye(s) 1 time/day at night. Do not exceed recommended dose.
The recommended dose is one drop of bimatoprost in the affected eye(s) once a day in the evening. Do not exceed recommended dose.
When more than one topical ophthalmic preparation is used, an interval of 5 minutes should be observed between the administration of each one.
Overdose
There were no cases of overdose with topical application. In case of overdose, treatment should be symptomatic and supportive.
Precautions and special instructions
There is no experience with the use of bimatoprost in patients with concomitant respiratory dysfunction, which requires caution in such patients. When conducting clinical studies in patients with respiratory failure, no significant adverse effects on the respiratory system were observed.
Bimatoprost has not been studied in patients with grade II or III AV block and in patients with uncontrolled congestive heart failure.
Before starting treatment, patients should be informed about the possibility of eyelash growth, darkening of the skin of the eyelids, and increased pigmentation of the iris. Some of these changes may be permanent and may result in differences in appearance between the eyes when only one eye is treated. The change in iris pigmentation occurs slowly and may not be noticeable for months or years. Very often, the change in the color of the iris is permanent. Iris color change is more associated with an increase in melanin content in melanocytes than with an increase in the number of melanocytes. The long-term effects of increased iris pigmentation are unknown. In typical cases, the brown pigment spreads from the area around the pupil to the root of the iris, as a result, the entire iris or parts of it become more brown. The use of bimatoprost does not affect nevi and lentigo iris. Periorbital tissue pigmentation is reversible in some patients.
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